3D-2drug maintains a portfolio of leading drug discovery projects capitalizing on emerging opportunities identified in-house, through collaborations and from scientific publications. We rapidly engage in creative approaches to new opportunities. Often, these are published externally. These opportunities are selected based on novelty and may be brought about through new information on important targets or new strategies on existing targets. In structure based projects, examples include new protein X-ray structures or newly identified sites for established structures. In ligand based projects, such examples include newly emerging, active chemical classes or structure activity modeling opportunities. Identifying these various opportunities in-house is a key strength of 3D-2drug. We welcome discussion with potential partners for collaboration on these in-house portfolio projects.